Dementia in old age
The researchers analyzed over 1,600 individuals for five “biomarkers” of inflammation in their blood when they had been, normally, 53 years of age. Approximately 24 decades after, the participants had been given brain scans and a memory test.
Compared to individuals who’d no increased levels of the biomarkers, people who have elevated amounts for three or more biomarkers had a mean of 5 percent reduced quantity in the hippocampus and other regions of the brain linked to Alzheimer’s disease. They also had lower scores on the memory test.
The study was published online Nov. 1 at the journal Neurology.
“These results indicate that inflammation at midlife could be an early contributor to the mind changes which are related to Alzheimer’s disease and other types of dementia,” said researcher Keenan Walker, by the Johns Hopkins University School of Medicine in Baltimore.
“Since the procedures that result in brain baldness start decades before people begin showing any signs, it’s essential that people determine how these procedures that occur in middle age influence individuals several years after,” Walker said in a diary information release.