For a young child with spastic cerebral palsy, only grasping a toy could not be possible. However, infusions of their own umbilical cord blood may make fundamental moves like this simpler, researchers state.
Children with spastic cerebral palsy have rigid muscles which could make it difficult to maneuver. The problem is usually brought on by brain damage before or at dawn.
“We’re encouraged with the results of the study, which demonstrates that appropriately dosed infusions of cord blood cells might help reduce symptoms in children with cerebral palsy,” said senior author Dr. Joanne Kurtzberg. She directs Duke University’s pediatric blood and marrow transplant program, in Durham, N.C.
The profits were subtle sometimes. But even a seemingly modest improvement is important, the researchers explained at a university news release.
“For instance, a child’s capacity to turn their hands from confronting down to facing up can alter their capacity to grasp or hold something, which may make a big difference in their daily life,” said lead author Dr. Jessica Sunsaid She is a pediatric hematologist-oncologist in Duke.
The study comprised 63 children with several forms and levels of spastic cerebral palsy.
The researchers found that people who received a single intravenous dose of cord blood together with at least 25 million stem cells per kilogram of body fat had improvements in motor functioning annually afterwards.
The developments have been greater compared to those who obtained a lower dose of stem cells along with a placebo. They were also larger than what’s typically found in children of comparable age and illness, according to the study authors.
Kurtzberg said there is still much to know concerning this treatment so that it can be available to more children with cerebral palsy.
“Now that we’ve identified a dosing threshold, we’re planning further studies analyzing the advantages of multiple doses of cells, in addition to using donor cells for individuals whose own cord blood wasn’t banked,” she explained.
Past research has suggested that it is safe for kids with cerebral palsy to get an infusion of the own cord blood, Kurtzberg said.
The analysis was that the second of three required for acceptance of a treatment in america. Outcomes were released Oct. 28 at the journal Stem Cells Translational Medicine.